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Amoxicillin and Clavulanate Potassium 1g Film Coated Tablet: Each film coated tablet contacines Amoxicillin Trihydrate USP equivalent to Amoxicillin 875mg and Clavulanate Potassium USP equivalent to Clavalanic acid 125mg.
Amoxicillin and Clavulanate Potassium is an oral antibacterial combination consiating of the semi synthetic broad-spectrum antibiotic Amoxicillin and the beta-lactamase enzyme inhibitor clavulanic acid, which protects amoxicilin from destruction and subsequent loss of antibacterial activity by the beta-lactamase enzyme produced by many gram-negative and gram-positive vacteria.
This conbination extends the spectrum of amoxicillin to include a wider range of organisms, including many resistant to other beta-lactam antibiotics. Amoxicillin and clavulanic acid are well absorbed from the gastrointestinal tract following oral administration of Amoxicillin and Clavulanate Potassium.
Amoxicillin and Clavulanate Potassium is bacterial against a wide range of beta-lactamase and non-beta-lactamase producing organisms including:
Gram-positive: and Gram-negative
Amoxicillin and Clavulanate Potassium is indicated for treatment of the following bacterial inlections due to susceptible organisms:
-Upper respiratory tract infection (including ENT) , e.g. tonsillitis, sinusitis, otitis media;
-Lower respiratory tract infections, e.g. actue and chronic bronchitis, lobar and bronchopneumonia.
-Gentio-urinary tract infection, e.g. cystitis, urethritis, pyelonephritis, pelvic infection, chancroid, gonorrhoea.
-Skin and soft tissue infection, e.g. boils, abscesses, cellulitis, animal bites, wound infections.
-Bone and joint infections, e.g. osteomyelitis
Dosage and Administration:
Amoxicillin and Clavulanate Potassiummay be administrated without regards to meals. However, to munimize potential pastrointestinal intolerance, administer at the start of a meal.
Adults and Children over 12 years:
Mild-Moderate infections: One Amoxicillin and Clavulanate Potassium 375mg tablet every 8 hours.
Severe infections: One Amoxicillin and Clavulanate Potassium 625mg tablet every 8 hours or one 1g tablet every 12 hours.
Severe dental infections( but not generally first-line): one KONN One Amoxicillin and Clavulanate Potassium 375mg tablet every 8hour lor 5 days.
Amoxicillin and Clavulanate Potassium should not be administrated to patients hypersensitive to penicillins, cephalosporins and other beta-lactams, It is also contraindicated in patients with a previous history of Amoxicillin and Clavulanate acid or penicillin-associated jaundice or hepatic dysfunction.
Use in Pregnancy and lactation:
As with all mediciens, use should be avoided in pregnancy, especially during the first trimester, unless considered essential by the physician.
Amoxicillin and Clavulanate Potassium may be administrated during the period of lactation.
With the exception of the risk of sensitization, associated with excretion of trace amounts in the breast milk, there are no significant effects to the infants.
Amoxicillin and Clavulanate Potassium is well tolerated. Side effects, as with amoxicillin, are uncommon and mainly of mild and transitory nature. The reported adverse effects include diarrhoea, nausea, vomiting, antibiotic-associated colitis, and candidiasis have been reported. Hepatitis and cholestatic jaundice have been reported rarely.
Prolongation of bleeding time and prothrombin time have been reported in some patients receving amoxicillin clavulanic acid. Amoxicillin and Clavulanate Potassium should be used with care in patients on anti-coagulant therapy,in common with other broad-spectrum antibiotics, Amoxicillin and Clavulanate Potassium may reduce the efficacy of oral contraceptives and patients should be wamed accordingly.
Store at room temperature below 30c, in a dry place, protected from light.